Dr.Levent KARAFAKI (Tel:0312 238 16 20 Mobil: 0530 738 16 20)

Ozone Safe, Effective for Knee Osteoarthritis Pain Intra-articular ozone may provide pain relief, functional improvement, and gains in quality of life (QoL) in patients with knee osteoarthritis (OA), according to a study recently published in PLoS One . 1 The intervention, which was conducted by a team of Brazilian researchers affiliated with the Sao Paulo Federal University in Brazil, was shown to be safe and effective. “Although many clinical series reports have been accomplished, no randomized, double-blind, placebo-controlled clinical trial had been accomplished until now,” said lead investigator Carlos César Lopes de Jesus, MD, in an interview with Clinical Pain Advisor. A total of 98 patients with symptomatic knee OA were enrolled in the trial and randomly assigned to receive intra-articular injections of ozone (20 μg/mL; n=63), or air (10 mL; n=35) once weekly for 8 weeks. Efficacy measures included the Visual Analogue Scale (VAS); Lequesne Index, in which patients w...

Could a chicory compound reduce Alzheimer's-related memory loss? Memory loss is a key characteristic of Alzheimer's disease, which is a condition that affects more than 5.4 million people in the United States. In a new study, researchers report that a compound called chicoric acid, naturally present in chicory, may be effective in reducing Alzheimer's-related memory loss. Researchers suggest that a compound found in chicory has the potential to reduce memory loss associated with Alzheimer's disease. The study, recently published in The FASEB Journal , reveals that mice treated with chicoric acid displayed better memory in behavioral tests than rodents that did not receive the compound. While further research is needed, study co-author Xuebo Liu, Ph.D., of the College of Food Science and Engineering at Northwest A&F University in China, and colleagues say that it is possible for chicoric acid to help maintain memory in patients with Alzheimer's and other ne...

Renoprotective effects of megadose vitamin C on cisplatin-induced kidney injury   Supa Sithanukul 1 Chollada Buranakarl 1* Chutamas Benjanirut 1 Anudep Rungsipipat 2 ABSTRACT      Cisplatin (CDDP)-induced nephrotoxicity is mediated via oxidative stress and may be alleviated using antioxidant activity. Although megadose of vitamin C may cause oxalate nephropathy and apoptosis, the antioxidant effect of vitamin C may be beneficial when given along with CDDP. The objective of this study was to investigate the renoprotective effects of megadose vitamin C on rats receiving CDDP. Rats were divided into 4 groups: group 1, control rats (CONT); group 2, vitamin C-treated rats (VIT C); group 3, CDDP-treated rats (CDDP) and group 4, CDDP + vitamin C-treated rats (CDDP + VIT C). Vitamin C (1000 mg/kg) was given intravenously to the VIT C and CDDP + VIT C groups while CDDP (6 mg/kg) was injected intraperitoneally into the CDDP and CDDP + VIT C groups. Renal func...