Ozone Safe, Effective for Knee Osteoarthritis Pain Intra-articular ozone may provide pain relief, functional improvement, and gains in quality of life (QoL) in patients with knee osteoarthritis (OA), according to a study recently published in PLoS One . 1 The intervention, which was conducted by a team of Brazilian researchers affiliated with the Sao Paulo Federal University in Brazil, was shown to be safe and effective. “Although many clinical series reports have been accomplished, no randomized, double-blind, placebo-controlled clinical trial had been accomplished until now,” said lead investigator Carlos César Lopes de Jesus, MD, in an interview with Clinical Pain Advisor. A total of 98 patients with symptomatic knee OA were enrolled in the trial and randomly assigned to receive intra-articular injections of ozone (20 μg/mL; n=63), or air (10 mL; n=35) once weekly for 8 weeks. Efficacy measures included the Visual Analogue Scale (VAS); Lequesne Index, in which patients w...
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