Ozone Safe, Effective for Knee Osteoarthritis Pain

Intra-articular ozone may provide pain relief, functional improvement, and gains in quality of life (QoL) in patients with knee osteoarthritis (OA), according to a study recently published in PLoS One.¹

The intervention, which was conducted by a team of Brazilian researchers affiliated with the Sao Paulo Federal University in Brazil, was shown to be safe and effective. “Although many clinical series reports have been accomplished, no randomized, double-blind, placebo-controlled clinical trial had been accomplished until now,” said lead investigator Carlos César Lopes de Jesus, MD, in an interview with Clinical Pain Advisor.

A total of 98 patients with symptomatic knee OA were enrolled in the trial and randomly assigned to receive intra-articular injections of ozone (20 μg/mL; n=63), or air (10 mL; n=35) once weekly for 8 weeks. Efficacy measures included the Visual Analogue Scale (VAS); Lequesne Index, in which patients with knee OA rate pain and function on a 0 to 24-point scale; Timed Up and Go Test, which evaluates balance and fall risk; SF-36 Health Survey Instrument, which evaluates QoL on a scale of 0 to 100 (0 =worst health); Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC); and the Geriatric Pain Measure (GPM).

After 8 weeks of treatment, statistically significant differences favoring ozone were seen in several efficacy measures. A significant reduction in pain as measured by VAS, GPM, and WOMAC scores was seen in the ozone group compared with the placebo group (P <.001). Differences in WOMAC scores, particularly toward the end of the treatment course, also indicated a significant improvement in joint stiffness and engagement in physical activities (P <.001). Lequesne Index measures also indicated a significant reduction in pain and improvement in function (P < .001), and QoL in relation to function, pain, and general physical and mental health was also statistically superior in the ozone group compared with the placebo group (P <.001). No significant differences were observed between groups in relation to the Timed Up and Go Test.

The study investigators reminded clinicians that symptomatic knee OA affects more than 9.3 million US adults and is a leading cause of disability. Agents to slow progression are lacking. Ozone therapy has been used as an alternative therapy in some chronic conditions such as rheumatic and osteoarthritic disease.

“In my opinion, ozone injections are more effective than the use of corticosteroids and nonsteroidal anti-inflammatory agents [NSAIDs] for the treatment of knee OA,” said Dr Lopes de Jesus. He explained that ozone has a significantly broader mechanism of action than NSAIDs and corticosteroids, providing anti-inflammatory and antioxidant effects and the ability to deter antalgic gait.² “Ozone activates the cellular metabolism, reduces prostaglandin synthesis, makes the redox system function properly by reducing oxidative stress through induction of the synthesis of antioxidant enzymes, and ameliorates tissue oxygen supply through hemorheologic action, vasodilatation, and angiogenic stimulation.“ Dr Lopes de Jesus added that ozone has been reported to have a restorative effect once it mobilizes bone marrow, mesenchymal, and endothelial stem cells, but no study had demonstrated this until now.

Puncture accidents, which occurred in 2 patients in the placebo group and 1 in the ozone group, were the only reported adverse events in this study. Adverse events are rare and comprise acute and transitory pain in the knee at the moment of ozone application, said Dr Lopes de Jesus.

The investigators concluded that their results are encouraging and warrant further study.

Summary and Clinical Applicability

The value of intra-articular ozone for pain relief and functional improvement in patients with knee osteoarthritis was confirmed in a randomized double-blind placebo-controlled clinical trial.

Limitations and Disclosures

According to Dr Lopes de Jesus, the main limitation of the current study was the lack of imaging examination control to evaluate the impact of treatment.

http://www.clinicalpainadvisor.com/arthritis/intra-articular-ozone-injections-shown-to-be-beneficial-for-knee-oa-pain/article/684149/

Mevcut yazılı metin bilgilendirme amaçlıdır. Bilimsel verilerden elde edilmiş bilgilerdir. Konu hakkında uzman kişiler tarafından yönlendirilmeniz ve tedaviye yönelik işlemleri bir hekim kontrolünde uygulamanız veya uygulatmanız önerilir. Ankara ozon , ozon ankara , alternatif kanser tedavisi , dmso , integratif tıp , akupunktur , biorezonans. 

Could a chicory compound reduce Alzheimer's-related memory loss?

Memory loss is a key characteristic of Alzheimer's disease, which is a condition that affects more than 5.4 million people in the United States. In a new study, researchers report that a compound called chicoric acid, naturally present in chicory, may be effective in reducing Alzheimer's-related memory loss.

Researchers suggest that a compound found in chicory has the potential to reduce memory loss associated with Alzheimer's disease.

The study, recently published in The FASEB Journal, reveals that mice treated with chicoric acid displayed better memory in behavioral tests than rodents that did not receive the compound.
While further research is needed, study co-author Xuebo Liu, Ph.D., of the College of Food Science and Engineering at Northwest A&F University in China, and colleagues say that it is possible for chicoric acid to help maintain memory in patients with Alzheimer's and other neurodegenerative conditions.
Alzheimer's disease is the most common form of dementia, accounting for approximately 60-80 percent of all cases. It is estimated that every 66 seconds, somebody in the U.S. develops Alzheimer's disease, and it is currently the sixth leading cause of death in the country.
One of the earliest signs of Alzheimer's disease is memory loss. It is often mild in the early stages of the disease, with individuals potentially having problems recalling recent events, for example. In the later stages, a person may not recognize familiar faces, recall the names of loved ones, or recognize once familiar surroundings.
There is currently no way to halt Alzheimer's-related memory loss, though there are medications that might help to reduce its severity for a limited time. For example, cholinesterase inhibitors delay the worsening of memory and other cognitive symptoms for approximately 6-12 months in around 50 percent of patients who use them.
Now, Liu and colleagues suggest that chicoric acid has the potential to offer a more natural strategy to reduce memory impairment.

Assessing the effects of chicoric acid on memory in mice

Chicoric acid, also referred to as cichoric acid, is a chemical compound found in at least 63 types of plants and vegetables, including chicory, lettuce, and basil.
Previous studies have shown that chicoric acid has antioxidant properties, meaning that it can reduce or even prevent some types of cell damage caused by oxidative stress.
For their study, Liu and team set out to investigate whether chicoric acid might protect against memory impairment induced by lipopolysaccharides (LPS). These are molecules that have been linked to brain cell damage through oxidative stress and neuroinflammation.
The team used three groups of mice to reach their findings. One group was treated with LPS, one was treated with both LPS and chicoric acid, and one was a control group.
The memory and learning abilities of all groups were tested using two behavioral tests: the Y-maze, which assesses rodents' willingness to explore new surroundings, and the Morris water maze, which tests rodents' ability to recall and navigate their surroundings.

Chicoric acid 'a plausible therapeutic intervention' for Alzheimer's

The researchers found that mice treated with LPS took longer to complete the mazes than mice treated with both LPS and chicoric acid, suggesting that chicoric acid can reduce LPS-induced memory impairment.
The study also revealed that chicoric acid decreased the buildup of beta-amyloid proteins induced by LPS treatment. Beta-amyloid proteins are known to form "plaques" in brain cells that are considered a precursor to Alzheimer's.
Furthermore, the team found that chicoric acid reduced neuroinflammation triggered by treatment with LPS in both mouse brains and microglial cells.
According to the researchers, these results suggest that chicoric acid could be a "plausible therapeutic intervention for neuroinflammation-related diseases such as Alzheimer's disease."
While the current results are promising, further research is needed to determine the effects that chicoric acid may have on memory impairment for patients with Alzheimer's.


Mevcut yazılı metin bilgilendirme amaçlıdır. Bilimsel verilerden elde edilmiş bilgilerdir. Konu hakkında uzman kişiler tarafından yönlendirilmeniz ve tedaviye yönelik işlemleri bir hekim kontrolünde uygulamanız veya uygulatmanız önerilir.Ankara ozon , ozon ankara , alternatif kanser tedavisi , dmso , integratif tıp , akupunktur ,

Renoprotective Effects of Megadose Vitamin C on cisplatin-induced kidney injury

Renoprotective effects of megadose vitamin C on cisplatin-induced kidney injury

 Supa Sithanukul1 Chollada Buranakarl1* Chutamas Benjanirut1 Anudep Rungsipipat2

ABSTRACT

     Cisplatin (CDDP)-induced nephrotoxicity is mediated via oxidative stress and may be alleviated using antioxidant activity. Although megadose of vitamin C may cause oxalate nephropathy and apoptosis, the antioxidant effect of vitamin C may be beneficial when given along with CDDP. The objective of this study was to investigate the renoprotective effects of megadose vitamin C on rats receiving CDDP. Rats were divided into 4 groups: group 1, control rats (CONT); group 2, vitamin C-treated rats (VIT C); group 3, CDDP-treated rats (CDDP) and group 4, CDDP + vitamin C-treated rats (CDDP + VIT C). Vitamin C (1000 mg/kg) was given intravenously to the VIT C and CDDP + VIT C groups while CDDP (6 mg/kg) was injected intraperitoneally into the CDDP and CDDP + VIT C groups. Renal function, oxidative stress, apoptosis and histopathology were investigated. At 5 days after injection, CDDP caused renal impairment as shown by significant increases in plasma concentrations of creatinine (PCr), urea nitrogen (PUN), urinary excretion of electrolytes (Na+, K+ and Cl-) and protein. Plasma malondialdehyde (P-MDA) and urinary MDA and creatinine ratio (U-MDA/Cr) were also increased. Kidney PCR products of antiapoptosis/proapoptosis (Bcl-2/Bax) were reduced by CDDP while histopathologic results showed severe massive tubular necrosis. Giving megadose vitamin C along with CDDP showed improvement on all renal function parameters and oxidative stress parameters except proteinuria. The vitamin C caused improvement on tubular cell lesions, but did not alter the Bcl-2/Bax level. It is concluded that megadose vitamin C can provide protection against CDDP-induced kidney injury by antioxidant activity.


Mevcut yazılı metin bilgilendirme amaçlıdır. Bilimsel verilerden elde edilmiş bilgilerdir. Konu hakkında uzman kişiler tarafından yönlendirilmeniz ve tedaviye yönelik işlemleri bir hekim kontrolünde uygulamanız veya uygulatmanız önerilir.Ankara ozon , ozon ankara , alternatif kanser tedavisi , dmso , integratif tıp , akupunktur, şelasyon, megadoz vitamin c, yüksek doz vitamin c.